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Generators

Generators

Ga

Gallium

Type: Generators

Tc

Technetium

Type: Generators

Re

Rhenium

Type: Generators

Gallium-68 Generator (Ge-68/Ga-68) (PET)

The Ga-68 generator uses a glass column with TiO2 sorbent to fix Ge-68, which decays to produce Ga-68. It is placed in a lead container and 0.1 M HCI is used to elute the Ga-68.

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Tc-99m Generator

Sodium molybdate (Mo-99) 2.5- 60 GBq corresponding to Sodium pertechnetate (Tc-99m) 2 - 50 GBq, radionuclide generator

A technetium-99m generator, also known as a technetium, is a device used to extract the metastable isotope 99mTc of technetium from a decaying sample of molybdenum-99. 99Mo has a half-life of 66 hours[1] and can be transported over long distances to hospitals where its decay product technetium-99m is extracted and used for a variety of nuclear medicine diagnostic procedures.

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Rhenium-188 is a beta-emitter with a 16.98-hour half-life, it may form complexes. It allows synthesizing radiopharmaceuticals for diagnostics and therapy of malignant tumors, bone metastases, rheumatoid arthritis and other diseases. The parent isotope is Tungsten-188.

The advantage of this generator is the presence of both beta- and gamma- radiation components (0.155 MeV); the first of these ensures a high therapeutic effect and the second one enables the operators to receive visual information in conventional gamma-cameras.

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Rhenium - 188 Generator

Characteristics

Manufacturing enterprise: IPPE.
Parent isotope's activity: 3,7; 5,5; 7,4; 18,5; 37,0 GBq.
Generator's weight: 16 kg (without package).
Lifetime: 40, 80, 110, 150, 200 days (depending on the generator's type).

Technical advantages

  • Short half-life period of Re-188 (17 hours) makes it safer for patients, staff and environment.

  • The presence of mean energy β-emission provides an optimal therapeutic dose for affecting pathology focus (tumors and other).

  • The presence of a γ-component with the energy of 155 keV in the emission spectrum makes it possible to monitor the behavior of the labeled pharmaceutical in the patient's body using SPECT.

  • Produced under Radiation Safety Standards-2009/2010.

  • The half-life period of parent W-188 radionuclide (69,4 days) makes it possible to use one generator within 6 to 12 months (depending on the generator rated activity).

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