RadioPharmaceuticals
Sodium molybdate (Mo-99) 2.5- 60 GBq corresponding to Sodium pertechnetate (Tc-99m) 2 - 50 GBq, radionuclide generator
A technetium-99m generator, also known as a technetium, is a device used to extract the metastable isotope 99mTc of technetium from a decaying sample of molybdenum-99. 99Mo has a half-life of 66 hours[1] and can be transported over long distances to hospitals where its decay product technetium-99m is extracted and used for a variety of nuclear medicine diagnostic procedures.
Tc-99m Generator
Rhenium-188 is a beta-emitter with a 16.98-hour half-life, it may form complexes. It allows synthesizing radiopharmaceuticals for diagnostics and therapy of malignant tumors, bone metastases, rheumatoid arthritis and other diseases. The parent isotope is Tungsten-188.
​
The advantage of this generator is the presence of both beta- and gamma- radiation components (0.155 MeV); the first of these ensures a high therapeutic effect and the second one enables the operators to receive visual information in conventional gamma-cameras.
Rhenium
Characteristics
Manufacturing enterprise: IPPE.
Parent isotope's activity: 3,7; 5,5; 7,4; 18,5; 37,0 GBq.
Generator's weight: 16 kg (without package).
Lifetime: 40, 80, 110, 150, 200 days (depending on the generator's type).
Technical advantages
-
Short half-life period of Re-188 (17 hours) makes it safer for patients, staff and environment.
-
The presence of mean energy β-emission provides an optimal therapeutic dose for affecting pathology focus (tumors and other).
-
The presence of a γ-component with the energy of 155 keV in the emission spectrum makes it possible to monitor the behavior of the labeled pharmaceutical in the patient's body using SPECT.
-
Produced under Radiation Safety Standards-2009/2010.
-
The half-life period of parent W-188 radionuclide (69,4 days) makes it possible to use one generator within 6 to 12 months (depending on the generator rated activity).
Lutetium-177
Lutetium-177 is a radioactive isotope used in cancer treatment and imaging, with a short half-life, high yield and purity, and the ability to target specific cancer cells while minimizing damage to healthy tissues.
Characteristics:
-
Lu-177 is a beta-emitting radioisotope with a half-life of 6.7 days.
-
It emits beta particles with an average energy of 134 keV and a maximum energy of 497 keV, which allows for effective tumor irradiation with minimal damage to surrounding healthy tissues.
-
Lu-177 can be produced via nuclear reactions using a cyclotron or nuclear reactor, and it is typically obtained by irradiating a stable isotope of lutetium with neutrons.
Technical advantages:
-
Lu-177 can be conjugated with various targeting agents, such as peptides, antibodies, or small molecules, to selectively deliver the radioactive payload to cancer cells expressing the corresponding receptor or antigen.
-
Lu-177 has a relatively short range in tissue (maximum of 1.7 mm), which enables selective killing of cancer cells with minimal collateral damage to normal tissues.
-
Lu-177 has a high yield and purity, and it can be conveniently radiolabeled with various chelators for stable complexation with targeting agents.
-
Lu-177 has a lower radiation exposure to medical staff and the environment compared to other therapeutic radionuclides, such as iodine-131 or yttrium-90.​
Medical applications:
-
Lu-177 is used in targeted radionuclide therapy (TRT) for the treatment of various cancer types, such as neuroendocrine tumors, prostate cancer, and metastatic bone pain.
-
In TRT, Lu-177 is administered systemically to the patient, and it accumulates preferentially in the tumor tissue, where it delivers its beta radiation and induces DNA damage and cell death.
-
Lu-177 TRT has shown high response rates, durable remissions, and improved quality of life in several clinical trials, especially in patients with limited therapeutic options or resistant disease.
-
Lu-177 can also be used in imaging applications, such as single-photon emission computed tomography (SPECT) or positron emission tomography (PET), when labeled with suitable imaging agents.
Gallium-68 Generator (Ge-68/Ga-68) (PET)
Nuclear medicine produces the positron-emitting radionuclide Ga-68 using a Ge-68/Ga-68 generator. With a half-life of 270.95 days, the parent isotope Ge-68 can be easily transported to hospitals as a generator and used there as the source of Ga-68 for at least a year. Gallium-68 can be readily eluted from the generator at any time at the site of application and is useful for a variety of things despite having a short half-life of only 67.71 minutes and being difficult to transport.
The Ga-68 generator uses a glass column with TiO2 sorbent to fix Ge-68, which decays to produce Ga-68. It is placed in a lead container and 0.1 M HCI is used to elute the Ga-68.
Technical advantages
-
The elute of Gallium-68 is 0.1 M HCI.
-
Ga-68 yield in 5 ml of eluent is at least 75 % at the first run and at least 45% throughout 3 years or after 400 elutions.
-
The breakthrough of Ge-68 is not more than 0.005 %.
-
The column is placed into a lead security container of the KSU-2NZH-M generator standard set.
-
The generator is certified in the certification system for equipment, products and technologies for nuclear installations, radiation sources and storage (OIT-certification system).
Application
Ga-68 obtained from this generator can be used for PET systems calibration, for making phantoms and for the development of labeling technique.
With Esentes Rapid Radio-Labeling kits
-
Advanced Technology
-
Proven Concept
-
Least Operator Error & Failure rate
-
Quick, Efficient & Safe
-
Short Time Procedures with High Yield
Tekcis® (SPECT)
Sodium molybdate (Mo-99) 2.5- 60 GBq corresponding to Sodium pertechnetate (Tc-99m) 2 - 50 GBq, radionuclide generator
A technetium-99m generator, also known as a moly cow or technetium cow, is a device used to extract the metastable isotope 99mTc of technetium from a decaying sample of molybdenum-99. 99Mo has a half-life of 66 hours[1] and can be transported over long distances to hospitals where its decay product technetium-99m is extracted and used for a variety of nuclear medicine diagnostic procedures.
Rhenium
Rhenium-188 is a beta-emitter with a 16.98-hour half-life, it may form complexes. It allows synthesizing radiopharmaceuticals for diagnostics and therapy of malignant tumors, bone metastases, rheumatoid arthritis and other diseases. The parent isotope is Tungsten-188.
The advantage of this generator is the presence of both beta- and gamma- radiation components (0.155 MeV); the first of these ensures a high therapeutic effect and the second one enables the operators to receive visual information in conventional gamma-cameras.
Characteristics
Manufacturing enterprise: IPPE.
Parent isotope's activity: 3,7; 5,5; 7,4; 18,5; 37,0 GBq.
Generator's weight: 16 kg (without package).
Lifetime: 40, 80, 110, 150, 200 days (depending on the generator's type).
Technical advantages
-
Short half-life period of Re-188 (17 hours) makes it safer for patients, staff and environment.
-
The presence of mean energy β-emission provides an optimal therapeutic dose for affecting pathology focus (tumors and other).
-
The presence of a γ-component with the energy of 155 keV in the emission spectrum makes it possible to monitor the behavior of the labeled pharmaceutical in the patient's body using SPECT.
-
Produced under Radiation Safety Standards-2009/2010.
-
The half-life period of parent W-188 radionuclide (69,4 days) makes it possible to use one generator within 6 to 12 months (depending on the generator rated activity).
Lutetium-177
Lutetium-177 is a radioactive isotope used in cancer treatment and imaging, with a short half-life, high yield and purity, and the ability to target specific cancer cells while minimizing damage to healthy tissues.
Characteristics:
-
Lu-177 is a beta-emitting radioisotope with a half-life of 6.7 days.
-
It emits beta particles with an average energy of 134 keV and a maximum energy of 497 keV, which allows for effective tumor irradiation with minimal damage to surrounding healthy tissues.
-
Lu-177 can be produced via nuclear reactions using a cyclotron or nuclear reactor, and it is typically obtained by irradiating a stable isotope of lutetium with neutrons.
Technical advantages:
-
Lu-177 can be conjugated with various targeting agents, such as peptides, antibodies, or small molecules, to selectively deliver the radioactive payload to cancer cells expressing the corresponding receptor or antigen.
-
Lu-177 has a relatively short range in tissue (maximum of 1.7 mm), which enables selective killing of cancer cells with minimal collateral damage to normal tissues.
-
Lu-177 has a high yield and purity, and it can be conveniently radiolabeled with various chelators for stable complexation with targeting agents.
-
Lu-177 has a lower radiation exposure to medical staff and the environment compared to other therapeutic radionuclides, such as iodine-131 or yttrium-90.​
Medical applications:
-
Lu-177 is used in targeted radionuclide therapy (TRT) for the treatment of various cancer types, such as neuroendocrine tumors, prostate cancer, and metastatic bone pain.
-
In TRT, Lu-177 is administered systemically to the patient, and it accumulates preferentially in the tumor tissue, where it delivers its beta radiation and induces DNA damage and cell death.
-
Lu-177 TRT has shown high response rates, durable remissions, and improved quality of life in several clinical trials, especially in patients with limited therapeutic options or resistant disease.
-
Lu-177 can also be used in imaging applications, such as single-photon emission computed tomography (SPECT) or positron emission tomography (PET), when labeled with suitable imaging agents.